Dr. J. P. Jasper is an analytical and stable isotopic organic chemist with a successful record in quantifying processes of industrial and academic interest.  He is experienced in fundamental and applied research, scientific consulting, and classroom teaching. He has proven abilities in solving analytical problems relating to: (i) differentiation and quantification of bulk organic matter and specific organic compounds (particularly, pharmaceuticals via the use of quantitative tracers in Product and Process Authenticity), (ii) metabolically-associated, molecular isotopic matters, and (iii) separation of complex mixtures of natural and synthetic organic compounds. He has special skills include developing coherent models from disparate data, composing scientific publications, and preparing and executing complex plans.

EDUCATION
Ph.D., The Massachusetts Institute of Technology/Woods Hole Oceanographic Institution Joint Program in Marine Chemistry, Marine Organic Chemistry, 1988. (Quantified the tracer relationships between natural biomarker concentrations and bulk chemical properties, and the transformation of specific organic compounds. Thesis Supervisor: Dr. Robert B. Gagosian, now Director and CEO of Woods Hole Oceanographic Institution)

B.A., The University of Chicago, Geophysical Sciences and Biology, 1981.
SUMMARY OF EXPERIENCE
Molecular Isotope Technologies, LLC, Niantic, CT (Formerly, Analytical Consultants, LLC) 1999 - Present.
Chief Scientific Officer in a chemical research and development firm specializing in analytical and isotopic organic chemistry, serving the pharmaceutical industry and government organizations.

• Designs and performs studies of pharmaceutical- and botanical isotopic provenance for major pharmaceutical companies and government organizations. Employs a multi-stable-isotopic approach to characterization mainly of industrially-produced products (Product and Process Authenticity).
• Initiated and co-chaired the American Chemical Society’s first "Pharmaceutical Authenticity and Forensic Analysis" meeting that took place in Tampa, Florida (April 25-27, 2004).
• Advises domestic and foreign government organizations on matters on matters of Isotope Product and Process Authenticity
• Performs analytical and stable isotopic research and developing instrumentation in both the research and development, and manufacturing divisions of major pharmaceutical companies.
• Developed an online stable isotopic instrument for testing the efficacy of novel drug candidates at a top pharmaceutical company.
• Published manuscripts on a variety of topics related to stable-isotopic product and process authenticity (MIT Articles.)

Drumbeat Dimensions, Inc., West Mystic, CT 1998 -1999.

Scientific Director in an intellectual property firm that specializes in producing documented guidance for managing the scientific and technological aspects of major pharmaceutical and biotechnological firms.

Analytical Consultants, Niantic, CT 1997 - 1998.

Principal Scientist who founded a chemical consulting firm specializing in analytical and isotopic organic chemistry, serving the pharmaceutical and food science industries.

Pfizer Inc. and Cultor, Inc., Groton, CT 1995 - 1997.

Research Scientist in the Analytical Organic Chemistry Group, working on triglycerides of the new, low-calorie fat substitute Salatrim/Benefat. (Pfizer was a major pharmaceutical firm with annual sales of $12 billion. Cultor was a major food science company with annual sales of $1.5 billion.)

University of Connecticut, The Marine Science and Technology Center, Groton, CT 1994-1995. Research Scientist and Adjunct Assistant Professor, serving as a marine organic chemist in an advanced research institute at the University of Connecticut dedicated to the study of marine sciences and technology.

Indiana University, Department of Chemistry, Bloomington, IN 1988-1994.

Postdoctoral Research Associate and Assistant Scientist in marine organic and isotopic chemistry who served in a laboratory recognized for the development of the isotope ratio monitoring/gas chromatograph-mass spectrometer (irmGCMS) that measures the ¹³C/¹²C ratios of individual compounds from complex mixtures. Using a combination of organic and isotopic methods, devised novel techniques.

ADDITIONAL CREDENTIALS
Scientific, industrial, and technical publications presented below.
Member of the American Chemical Society (ACS), American Society Mass Spectrometry (ASMS), American Association of Pharmaceutical Sciences (AAPS), American Geophysical Union (AGU), the Connecticut Separation Sciences Council (CSSC), and the Connecticut Mass Spectrometry Discussion Group (CTMSDG).

Functional in the Spanish language

Contact Dr. Jasper at JPJasper@MolecularIsotopes.com or at  JPJasper@NaturesFingerprint.com.

(See MIT LLC Articles on Product and Process Authenticity)
 

Wokovich, A. M., J. A. Spencer, B. J. Westenberger, L. F. Buhse, and J. P. Jasper (2005)  Stable isotopic composition of the Active Pharmacetuical Ingredient (API) Naproxen.  J. Pharm. Biomed. Anal. 38:781-784.

Jasper, J.P., R.C. Lyon, and L.E. Weaner (2005) Stable isotopes provide a new PAT [Process Analytical Technology] tool.  Pharm. Mfg. 4(5):28-33.

Jasper, J. P., L. E. Weaner, and B. J. Duffy (2005) A preliminary multi-stable-isotopic evaluation of three synthetic pathways of Topiramate.  J. Pharm. Biomed. Anal. 39:66-75.

Jasper, J. P., L. E. Weaner, and B. J. Duffy (2004). A preliminary multi-stable isotopic evaluation of Topiramate. Forensic Isotope Ratio Mass Spectrometry (FIRMS) Newsletter 2(2):8-9.

Jasper, J. P. (2004) Pharmaceutical security: Using stable isotopes to authenticate pharmaceutical materials. Tablets and Capsules 2(3):37-42.

Jasper, J. P., B. J. Westenberger, J. A. Spencer, L. F. Buhse, and M. Nasr (2004).  Stable isotopic characterization of active pharmaceutical ingredients. J. Pharm. Biomed. Anal. 35:21-30.

Jasper, J. P., F. Fourel, A. Eaton, J. Morrison, and A. Phillips (2004). Stable isotopic characterization of analgesic drugs. Pharm. Technol. 28(8):60-67, (abstract presented at May, 2001 Am. Soc. Mass Spec., Chicago, Illinois).

Jasper, J.P., J. S. Edwards, L. C. Ford and R.A. Corry. (2002). Putting the arsonist at the scene: "DNA" for the fire investigator? Gas chromatography/isotope ratio mass spectrometry. Fire Arson Investig. 51(2): 30-34. (Also see linked scientific paper within Arson section.)

Jasper, J. P. (2001). Quantitative estimates of precision for molecular isotopic measurements. Rap. Comm. Mass Spec. 15:1554-1557.

Jasper, J. P. (1999). The increasing use of stable isotopes in the pharmaceutical industry. Pharm. Tech. 23(10):106-114.

Bidigare, R. R., A. Fluegge, K. H. Freeman, K. L. Hanson, J. M. Hayes, D. Hollander, J. P. Jasper, L. L. King, E. A. Laws, F. J. Millero, R. Pancost, B. N. Popp, P. A. Steinberg and S. G. Wakeham (1997). Consistent fractionation of 13C in nature and in the laboratory: Growth-rate effects in some haptophyte algae. Glob. Biogeochem. Cycl. 11:279-292.

Jasper, J. P. (1995). Biomarkers and bulk organic sources record a history of sedimentary decoupling: Results and a model. In Organic Geochemistry: Developments and Applications to Energy, Climate, Environment and Human History. (J. O. Grimalt and C. Dorronsoro, eds.) The Basque Country, Spain: A.I.G.O.A., pp. 817-819.

Jasper, J. P., E. L. Sikes and J. M. Hayes (1995). Transfer of CO2 from equatorial latitudes to high latitudes during the late Quaternary. In Air-Water Gas Transfer (B. Jahne and E. Monahan, eds.) Heidelberg: Aeon-Verlag, pp. 879-888.

Jasper, J. P., A. C. Mix, F. G. Prahl and J. M. Hayes (1994). Photosynthetic 13C fractionation and estimated CO2 levels in the Central Equatorial Pacific over the last 255,000 years. Paleoceanography 9:781-799. (Reviewed by S. O'Connell in Geotimes (40:46) as one of the "1994 Geoscience Highlights.")

Jasper, J. P. and J. M. Hayes (1994). Reconstruction of paleoceanic PCO2 levels from carbon isotopic compositions of sedimentary biogenic components. In Carbon Cycling in the Glacial Ocean: Constraints on the Ocean's Role in Global Change (M. Kaminiski, L. D. Laberyrie,T. F. Pedersen, and R. Zahn, eds.) Berlin: Springer-Verlag, pp. 323-341.

Jasper, J. P. and J. M. Hayes (1990). A carbon isotope record of CO2 levels during the late Quaternary. Nature 347:462-464. (Reviewed by N. J. Shackleton in Nature (347:427-428) "News and Views" article).


Jasper, J. P. (2000). GC-FID- and acyl carbon number-based determination of characteristic groupings of complex triglyceride (Benefat S and other) mixtures. J. Agric. Food Chem., 48(3):785-791

Jasper, J. P. and R. B. Gagosian (1993). The relationship between sedimentary organic carbon isotopic composition and lipid biomarker concentrations in the late Quaternary Pigmy Basin. Geochim. Cosmochim. Acta 57:167-186.

Jasper, J. P. and R. B. Gagosian (1989). Alkenone molecular stratigraphy in an oceanic environment affected by glacial meltwater events. Paleoceanography 4(6):603-614.

Jasper, J. P. (1988). An organic geochemical [tracer and stability analysis] approach to problems of glacial-interglacial climatic variability. Ph.D. thesis. MIT/WHOI, WHOI-88-28.
Bulk Isotopic and Elemental Compositions

Jasper, J. P. and J. M. Hayes (1993). Refined estimation of marine and terrigenous contributions to sedimentary organic carbon. Glob. Biogeochem. Cycl.7:451-461.

Jasper, J. P. and W. G. Deuser (1993). Annual cycles of mass flux and isotopic composition of pteropod shells settling into the deep Sargasso Sea. Deep-Sea Res. 40:653-669.

Jasper, J. P. and R. B. Gagosian (1990). The sources and deposition of organic matter in the late Quaternary Pigmy Basin, Gulf of Mexico. Geochim. Cosmochim. Acta 54:1117-1132.

Jasper, J. P. and R. B. Gagosian (1989). Glacial-interglacial climatically-forced 13C variations of sedimentary organic matter. Nature 342:60-62.


Whelan, J. K., J. M. Hunt, J. P. Jasper and A. Huc (1984). Migration of C1-C8 hydrocarbons in marine sediments. Org. Geochem. 6:683-694.

Jasper, J. P., J. K. Whelan and J. M. Hunt (1983). Migration of C1 to C8 volatile organic compounds in sediments from the Deep Sea Drilling Project, Leg 75, Hole 530A, Walvis Ridge. In Initial Reports D.S.D.P. 75 (A. H. Bouma, J. M. Coleman and A. W. Meyer, eds.) Washington, D.C.: U.S. Government Printing Office, pp. 1001-1008.


Jasper, J. P. (1998). GC-FID- and acyl carbon number-based determination of characteristic groupings of complex triglyceride (Salatrim 23MSO) mixtures, 16 pp. Pfizer-Cultor Research and Development.

Jasper, J. P. (1997). Gas chromatographic analysis of Salatrim positional isomers using an experimental gas chromatographic column, 7 pp., Pfizer-Cultor Research and Development.

Ordonio-Haas, G. and J. P. Jasper (1997). Quantification of acetic acid and acetic anhydride in recycled Salatrim process streams by GC-FID, 4 pp., Pfizer-Cultor Research and Development.

Ordonio-Haas, G. and J. P. Jasper (1996). Composition of Salatrim by GC-FID: Comprehensive and in-process methods, 10 pp., Pfizer Research and Development.

Pisias, N. G., W. Prell, F. Prahl, M. Delaney, D. Lea, J. Jasper, B. Popp, G. Rau, R. Murray, D. McCorkle, D. Rea, L. Derry and Workshop Participants (1995). Marine aspects of earth system history (MESH) proxy development workshop report, 75 pp., U.S. Global Change Research Program.